Raybourne R, Desowitz R S, Kliks M M, Deardorff T L
Exp Parasitol. 1983 Jun;55(3):289-98. doi: 10.1016/0014-4894(83)90025-5.
Excretory-secretory products were collected from supernatants of in vitro cultures of larval nematodes, Anisakis simplex (type I) and Terranova sp. (Hawaii type A). These materials were found to be more potent inhibitors of rodent lymphocyte blast transformation induced by concanavalin A and bacterial lipopolysaccaride than whole worm extracts of the same parasites. Inhibition of blast transformation was a result of cytostatic rather than toxic effects on proliferating lymphoid cells. The material(s) responsible for suppression are greater than 10,000 MW and are heat labile.
排泄分泌产物是从幼虫线虫简单异尖线虫（I型）和新海兽蛔线虫（夏威夷A型）的体外培养上清液中收集的。这些物质被发现比相同寄生虫的全虫提取物更能有效抑制伴刀豆球蛋白A和细菌脂多糖诱导的啮齿动物淋巴细胞母细胞转化。母细胞转化的抑制是对增殖性淋巴细胞产生细胞抑制作用而非毒性作用的结果。负责抑制的物质分子量大于10000道尔顿且对热不稳定。
