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将大鼠脑突触小泡固定在带正电荷的玻璃微球上。

Immobilization of rat brain synaptic vesicles on positively-charged glass microspheres.

作者信息

Disbrow J K, Gershten M J, Ruth J A

出版信息

Experientia. 1983 Jun 15;39(6):623-5. doi: 10.1007/BF01971130.

DOI:10.1007/BF01971130
PMID:6852201
Abstract

Synaptic vesicles from rat brain were immobilized on glass microspheres covalently coated with poly-L-lysine. Using a potassium tartrate perfusion medium, the vesicular accumulation and methamphetamine-induced release of (L)-3H-norephinephrine could be conveniently monitored in a flow experiment.

摘要

来自大鼠大脑的突触小泡被固定在共价包被有聚-L-赖氨酸的玻璃微球上。使用酒石酸钾灌注培养基，在流动实验中可以方便地监测（L）-3H-去甲肾上腺素的囊泡积累和甲基苯丙胺诱导的释放。

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Age-dependence of inhibition of rat brain synaptic vesicle [3H]norepinephrine uptake caused by administration of a single dose of reserpine: persistence of inhibition in adults but not in neonates.单剂量利血平给药对大鼠脑突触小泡[3H]去甲肾上腺素摄取抑制作用的年龄依赖性：抑制作用在成年大鼠中持续存在，而在新生大鼠中则不然。
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本文引用的文献

1
Greatly extended viability of rat brain storage vesicles in an intracellular medium based upon a non-permeant polyanion.基于非渗透性聚阴离子的细胞内培养基中大鼠脑储存囊泡的存活期大大延长。
Life Sci. 1981 Nov 9;29(19):1989-96. doi: 10.1016/0024-3205(81)90608-1.
2
Mechanisms of accumulation of tyramine, metaraminol, and isoproterenol in isolated chromaffin granules and ghosts.酪胺、间羟胺和异丙肾上腺素在分离的嗜铬粒和空泡中的蓄积机制。
Biochem Pharmacol. 1982 Mar 1;31(5):815-23. doi: 10.1016/0006-2952(82)90468-3.
3
The synaptic vesicle: calcium ion binding to the vesicle membrane and its modification by drug action.
突触小泡：钙离子与小泡膜的结合及其药物作用的修饰。
Mol Pharmacol. 1976 Sep;12(5):778-88.
4
Plasma membrane: rapid isolation and exposure of the cytoplasmic surface by use of positively charged beads.质膜：利用带正电荷的珠子快速分离并暴露细胞质表面。
Science. 1977 Jan 21;195(4275):302-4. doi: 10.1126/science.831278.
5
Coupling polylysine to glass beads for plasma membrane isolation.将聚赖氨酸与玻璃珠偶联用于质膜分离。
Biochim Biophys Acta. 1978 Jan 4;506(1):81-96. doi: 10.1016/0005-2736(78)90436-4.
6
Uptake of (-) 3H-norepinephrine by storage vesicles prepared from whole rat brain: properties of the uptake system and its inhibition by drugs.
Life Sci. 1977 Oct 15;21(8):1075-85. doi: 10.1016/0024-3205(77)90105-9.