Arushanian E B, Dutov A A
Farmakol Toksikol. 1983 Mar-Apr;46(2):24-8.
Electrolytic injury to dopaminergic neurons of the mesencephalic tegmentum in cats produced a steady experimental torticollis (ET) with contralateral turning of the head and body. DOPA potentiated and haloperidol mostly reduced ET. Analogous changes were induced by electrical stimulation of the ipsi- and contralateral caudate nucleus, respectively. Stimulation of the contralateral nucleus coupled with haloperidol administration led to a more pronounced restriction of ET. Unexpectedly, the same result was obtained after DOPA administration coupled with stimulation of the ipsi-lateral caudate nucleus. It is suggested that pharmacological treatment of torsion diseases should be combined with physical treatment methods.
猫中脑被盖多巴胺能神经元的电解损伤产生了一种稳定的实验性斜颈（ET），头部和身体向对侧扭转。左旋多巴可增强ET，而氟哌啶醇大多可减轻ET。分别对同侧和对侧尾状核进行电刺激也可诱导出类似变化。刺激对侧尾状核并给予氟哌啶醇会导致ET的限制更为明显。出乎意料的是，给予左旋多巴并刺激同侧尾状核后也得到了相同的结果。有人提出，扭转疾病的药物治疗应与物理治疗方法相结合。
