[Effect of substances altering the metabolism of endogenous serotonin on mitotic activity in the regenerating liver of mice].

The serotonin (S) precursor 5-hydroxytryptophan and MAO inhibitor o-chlorpargyline injected alone or combined increase the endogenous S level in the regenerating liver and stimulate mitotic activity. The tryptophan hydroxylase inhibitor p-chlorophenylalanine and reserpine decrease both the endogenous S level and the mitotic index (MI). There is a close correlation between the endogenous S level and the MI.