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[改变内源性5-羟色胺代谢的物质对小鼠再生肝有丝分裂活性的影响]

[Effect of substances altering the metabolism of endogenous serotonin on mitotic activity in the regenerating liver of mice].

作者信息

Kulinskiĭ A S, Saratikov A S, Vstavskaia Iu A, Udovitsina T I

出版信息

Farmakol Toksikol. 1983 Mar-Apr;46(2):92-5.

PMID:6852225
Abstract

The serotonin (S) precursor 5-hydroxytryptophan and MAO inhibitor o-chlorpargyline injected alone or combined increase the endogenous S level in the regenerating liver and stimulate mitotic activity. The tryptophan hydroxylase inhibitor p-chlorophenylalanine and reserpine decrease both the endogenous S level and the mitotic index (MI). There is a close correlation between the endogenous S level and the MI.

摘要

血清素(S)前体5-羟色氨酸和单胺氧化酶抑制剂邻氯苯丙胺单独注射或联合注射可提高再生肝脏中的内源性S水平,并刺激有丝分裂活性。色氨酸羟化酶抑制剂对氯苯丙氨酸和利血平可降低内源性S水平和有丝分裂指数(MI)。内源性S水平与MI之间存在密切相关性。

相似文献

1
[Effect of substances altering the metabolism of endogenous serotonin on mitotic activity in the regenerating liver of mice].[改变内源性5-羟色胺代谢的物质对小鼠再生肝有丝分裂活性的影响]
Farmakol Toksikol. 1983 Mar-Apr;46(2):92-5.
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An anticancer drug prospidine: failure to reveal antimitotic and clastogenic action on regenerating mouse liver.一种抗癌药物丙帕他啶:对再生小鼠肝脏未显示出抗有丝分裂和致染色体断裂作用。
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