Trotter J A, Scordilis S P, Margossian S S
FEBS Lett. 1983 May 30;156(1):135-40. doi: 10.1016/0014-5793(83)80264-6.
A number of motile functions of macrophages are thought to be mediated by myosin. We have observed that myosin from rabbit alveolar macrophages is heterogeneous with respect to its 20 kDa light chain: two species of 20 kDa light chain are identified by one-dimensional and two-dimensional polyacrylamide gel electrophoresis, in a ratio of 2:1. Native myosin, analyzed on non-denaturing gels, is also composed of two species, in a ratio of 2:1. These results indicate that macrophages contain at least two different myosins, which might have different physiological functions.
巨噬细胞的许多运动功能被认为是由肌球蛋白介导的。我们观察到，兔肺泡巨噬细胞的肌球蛋白在其20 kDa轻链方面具有异质性：通过一维和二维聚丙烯酰胺凝胶电泳鉴定出两种20 kDa轻链，比例为2:1。在非变性凝胶上分析的天然肌球蛋白也由两种类型组成，比例为2:1。这些结果表明，巨噬细胞至少含有两种不同的肌球蛋白，它们可能具有不同的生理功能。
