Eytan G D, Almary T
FEBS Lett. 1983 May 30;156(1):29-32. doi: 10.1016/0014-5793(83)80241-5.
Melittin-induced fusion of acidic liposomes. Fusion was observed in the electron-microscope and assayed as intermixing of both liposomes' contents and membranes. The melittin concentrations required for fusion induction were in the microM range compared to over 10 mM Ca2+ required for a comparable effect. It is suggested that the high efficiency of melittin is due to its amphipathic nature. Its hydrophobic moiety is probably anchored in one liposome while the positively charged hydrophilic moiety attracts another liposome.
蜂毒肽诱导酸性脂质体融合。在电子显微镜下观察到融合现象，并通过脂质体内容物和膜的混合来测定。与产生类似效果所需的超过10 mM Ca2+相比，诱导融合所需的蜂毒肽浓度在微摩尔范围内。有人认为蜂毒肽的高效性归因于其两亲性。其疏水部分可能锚定在一个脂质体中，而带正电荷的亲水部分则吸引另一个脂质体。
