Fukuma K, Fukushima T, Matsuo I, Mimori H, Maeyama M
Fertil Steril. 1983 Jun;39(6):780-4. doi: 10.1016/s0015-0282(16)47117-7.
The glycogen content, glycogen synthetase level, and glycogen phosphorylase level were studied in endometrial samples obtained from 14 infertile patients during the midluteal phase before and after clomiphene citrate (Clomid, Shionogi & Company, Ltd., Osaka, Japan) treatment, simultaneously with measurement of the serum concentrations of estradiol and progesterone. Increase in the endometrial glycogen content in the clomiphene cycle was accompanied by a corresponding increase of the dosage of clomiphene. Also, the midluteal concentrations of estradiol and progesterone in the clomiphene cycle were significantly higher (P less than 0.005 and P less than 0.005, respectively) than those in the nontreatment cycle. Clomiphene therapy at 50 mg/day resulted in pregnancy in three of ten patients, while clomiphene at 100 mg/day resulted in pregnancy in three of six patients. These results suggest a fair correlation between the dosage of clomiphene and the improvement of endometrial function in infertile patients following stimulated ovarian steroidogenesis.
对14例不孕患者在服用枸橼酸氯米芬（Clomid，日本盐野义制药株式会社，大阪）治疗前后的黄体中期采集的子宫内膜样本，研究了糖原含量、糖原合成酶水平和糖原磷酸化酶水平，同时测定了血清雌二醇和孕酮浓度。枸橼酸氯米芬周期中子宫内膜糖原含量的增加伴随着枸橼酸氯米芬剂量的相应增加。此外，枸橼酸氯米芬周期中黄体中期的雌二醇和孕酮浓度显著高于（分别为P<0.005和P<0.005）非治疗周期。每天50mg的枸橼酸氯米芬治疗使10例患者中的3例妊娠，而每天100mg的枸橼酸氯米芬使6例患者中的3例妊娠。这些结果表明，枸橼酸氯米芬的剂量与刺激卵巢甾体生成后不孕患者子宫内膜功能的改善之间存在一定的相关性。
