通过多次应用的血管收缩试验评估的局部用类固醇可能的给药方案。

Possible dosage regimens for topical steroids, assessed by vasoconstrictor assays using multiple applications.

作者信息

Woodford R, Haigh J M, Barry B W

出版信息

Dermatologica. 1983;166(3):136-40. doi: 10.1159/000249855.

Abstract

The bioavailabilities and activities of three amcinonide preparations and Betnovate cream were assessed using three multiple-dosage regimen vasoconstrictor assays in 10 volunteers. Applications were made once daily, twice daily and every alternate day with an initial three times daily loading dose applied on the first day only. Blanching responses first increased and then decreased due to tachyphylaxis. It is proposed that clinically the most advantageous dosage regimen is a once daily application with no loading dose.

摘要

在10名志愿者中，使用三种多剂量方案血管收缩剂试验评估了三种安西奈德制剂和倍他米松新霉素乳膏的生物利用度和活性。分别采用每日一次、每日两次和隔日一次的给药方式，仅在第一天给予初始每日三次的负荷剂量。由于快速耐受，皮肤苍白反应先增加后减少。建议临床上最有利的给药方案是每日一次给药且无负荷剂量。