源自原始肾上腺皮质癌的转移组织中类固醇生物合成的实验证据。
Experimental evidence for biosynthesis of steroids in metastatic tissue originating from a primitive adrenocortical carcinoma.
作者信息
Touitou Y, Bogdan A, Auzeby A
出版信息
Int J Biochem. 1983;15(4):571-3. doi: 10.1016/0020-711x(83)90133-7.
PMID:6852356
Abstract
- Cortisol, cortisone, 11-deoxycortisol and deoxycorticosterone were synthesized in large amounts in vitro by a metastatic tissue from an adrenocortical carcinoma. 2. Both 11 beta- and 21-hydroxylase were very active. 3. A secreting metastasis can be thus responsible for a biological relapse. 4. A metastasis originating from another secreting adrenocortical carcinoma was found to be non-secreting.
摘要
- 来自肾上腺皮质癌的转移组织在体外大量合成皮质醇、可的松、11-脱氧皮质醇和脱氧皮质酮。2. 11β-羟化酶和21-羟化酶均非常活跃。3. 因此，分泌性转移可能导致生物学复发。4. 发现源自另一个分泌性肾上腺皮质癌的转移灶不具有分泌功能。
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