Fuller P W, Guthrie R D, Alvord E C
Dev Med Child Neurol. 1983 Apr;25(2):214-31. doi: 10.1111/j.1469-8749.1983.tb13746.x.
This study aimed at providing understanding of the etiology and mechanisms responsible for the learning and behavioral disabilities in the increasing numbers of survivors of neonatal intensive care units who develop MBD/LD-type (minimal brain dysfunction, learning disabilities) complications. The brains of 16 premature infants who died within the first month of life were studied by microscopic examination. Significant neuropathological findings in gray-matter and white-matter were found in many areas, including both superficial cortical and deep basal brain structures. These lesions are postulated to be precursors to later LD and MBD syndromes in infants who survive, such that similar lesions of varying severity correlate with varying degrees of brain dysfunction. Premature infants who survive are known from other studies to be high-risk candidates for LD- and MBD- type developmental disabilities.
本研究旨在了解越来越多新生儿重症监护病房幸存者出现MBD/LD型（轻度脑功能障碍、学习障碍）并发症的病因及机制。对16例出生后第一个月内死亡的早产儿大脑进行了显微镜检查。在许多区域发现了灰质和白质中显著的神经病理学发现，包括浅表皮质和深部基底脑结构。这些病变被认为是存活婴儿后期LD和MBD综合征的先兆，不同严重程度的类似病变与不同程度的脑功能障碍相关。其他研究表明，存活的早产儿是LD和MBD型发育障碍的高危人群。
