Chevillotte G, Durbec J P, Gerolami A, Berthezene P, Bidart J M, Camatte R
Gastroenterology. 1983 Jul;85(1):141-5.
The relationship between alcohol consumption and the presence of seric hepatitis B virus markers has been studied in 125 male patients with liver cirrhosis and 126 control subjects. Mean daily alcohol consumption was found to be higher in patients than in controls. Hepatitis B virus seric markers were also more frequently observed in patients than in controls (53.6% vs. 36.5%, 2p less than 0.05). This was due to the greater frequency of hepatitis B core antibody alone or with hepatitis B surface antigen in the patients (2p less than 0.05). The possible interaction between alcohol and B virus was studied by log-linear hierarchic models for contingency tables. Data were displayed in a three-way classification frequency table (diagnosis, daily alcohol consumption, and hepatitis B virus seric markers). A model assuming that alcohol and seric markers of unresolved infection by hepatitis B virus are independently linked to cirrhosis gives the better goodness of fit between observed and estimated frequencies. The result however, suggests, that hepatitis B virus infection does not increase the influence of alcohol consumption on the production of cirrhosis.
对125例肝硬化男性患者和126例对照者研究了饮酒与血清乙肝病毒标志物存在情况之间的关系。发现患者的平均每日饮酒量高于对照者。患者中乙肝病毒血清标志物的检出频率也高于对照者（53.6%对36.5%，P<0.05）。这是由于患者中单独乙肝核心抗体或伴有乙肝表面抗原的频率更高（P<0.05）。通过对数线性分层模型对列联表研究了酒精与B病毒之间可能的相互作用。数据显示在一个三维分类频率表中（诊断、每日饮酒量和乙肝病毒血清标志物）。一个假设酒精和未解决的乙肝病毒感染血清标志物与肝硬化独立相关的模型在观察频率和估计频率之间给出了更好的拟合优度。然而，结果表明，乙肝病毒感染不会增加饮酒对肝硬化发生的影响。
