母亲在孕期服用丙硫氧嘧啶的儿童的智力发育
Intellectual development in children whose mothers received propylthiouracil during pregnancy.
作者信息
Burrow G N, Klatskin E H, Genel M
出版信息
Yale J Biol Med. 1978 Mar-Apr;51(2):151-6.
Abstract
Standard intelligence tests were administered to twenty-eight children who had been exposed to PTU in utero and thirty-two non-exposed siblings. There was no significant difference in results between the two groups. The present study suggests that with careful attention, pregnant women with thyrotoxicosis can be treated with propylthiouracil without interfering with subsequent intellectual development in the offspring.
摘要
对28名在子宫内接触过丙硫氧嘧啶（PTU）的儿童和32名未接触过的同胞兄弟姐妹进行了标准智力测试。两组结果之间没有显著差异。本研究表明，只要给予密切关注，患有甲状腺毒症的孕妇可以用丙硫氧嘧啶进行治疗，而不会干扰后代随后的智力发育。
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本文引用的文献
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FETAL HYPOTHYROIDISM. I. EFFECTS OF THYROXINE ON NEURAL DEVELOPMENT. II. FETAL VERSUS MATERNAL CONTRIBUTIONS TO FETAL THYROXINE REQUIREMENTS. III. CLINICAL IMPLICATIONS.胎儿甲状腺功能减退症。一、甲状腺素对神经发育的影响。二、胎儿与母体对胎儿甲状腺素需求的贡献。三、临床意义。
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