Houin G, Tremblay D, Bree F, Dufour A, Ledudal P, Tillement J P
Int J Clin Pharmacol Ther Toxicol. 1983 Mar;21(3):130-4.
The pharmacokinetic parameters and relative availability of niflumic acid in two different pharmaceutical preparations were studied in 12 subjects after a single oral administration. Total plasma clearance averaged 45 ml/min, and the half-life of elimination approximately 2 h, giving a distribution volume of 0.12 l/kg on the average. The values of these pharmacokinetic parameters were in agreement with the general characteristics of this type of substance, a weak acid strongly bound to plasma proteins. Comparison of the systemic availability of the two oral forms showed no difference; they were probably close to 100%.
在12名受试者单次口服给药后，研究了两种不同药物制剂中尼氟酸的药代动力学参数和相对生物利用度。血浆总清除率平均为45 ml/min，消除半衰期约为2小时，平均分布容积为0.12 l/kg。这些药代动力学参数值与这类物质（一种与血浆蛋白紧密结合的弱酸）的一般特征相符。两种口服剂型的全身生物利用度比较显示无差异；它们可能接近100%。
