Schlumberger M, Charbord P, Fragu P, Gardet P, Lumbroso J, Parmentier C, Tubiana M
J Clin Endocrinol Metab. 1983 Jul;57(1):148-51. doi: 10.1210/jcem-57-1-148.
To examine whether the injection of bovine TSH (bTSH) produces maximal radioactive iodine uptake (RAIU) in lung metastases in patients with differentiated thyroid cancer, 10 patients were studied 12 times. In 10 of these studies, an initial RAIU measurement was performed immediately after 3 injections of 10 IU bTSH given immediately after T3 withdrawal. Another RAIU measurement was performed 7-19 days after T3 withdrawal. Uptake increased in all patients even when it was clearly detectable immediately after bTSH stimulation. Thus, 3 days of bTSH stimulation in these patients did not lead to maximal 131I uptake, and it could only be reached after prolonged endogenous TSH stimulation. bTSH was not injected in the 2 other patients, in whom 6 RAIU measurements were carried out. Radioiodine uptake increased with time in both patients. It appears that both the level of endogenous TSH and the length of stimulation play a determining role in RAIU. This might explain why 3 days of bTSH stimulation are insufficient to elicit maximal 131I uptake.
为了研究注射牛促甲状腺激素（bTSH）是否能使分化型甲状腺癌患者肺转移灶的放射性碘摄取（RAIU）达到最大值，对10例患者进行了12次研究。在其中10次研究中，在停用T3后立即注射3次10 IU的bTSH，之后立即进行首次RAIU测量。在停用T3后7 - 19天进行了另一次RAIU测量。即使在bTSH刺激后立即能明显检测到摄取，所有患者的摄取量仍有所增加。因此，在这些患者中，3天的bTSH刺激并未导致最大的131I摄取，只有在内源性TSH长期刺激后才能达到最大值。另外2例患者未注射bTSH，对其进行了6次RAIU测量。两名患者的放射性碘摄取均随时间增加。看来内源性TSH水平和刺激时间在RAIU中都起着决定性作用。这可能解释了为什么3天的bTSH刺激不足以引发最大的131I摄取。
