Pinelis V G, Poliak M G, Markov K H
Kardiologiia. 1983 Mar;23(3):102-7.
Renal perfusion with Tyrode solution to which gelatinol was added revealed gradual development of structural changes in renal vessels as arterial hypertension was developing and stabilizing in spontaneously hypertensive rats, as evidenced by shifts in "perfusion pressure--perfusion rate" and "glomerular filtration rate--perfusion pressure" curves, increased afferent/efferent arteriole resistance ratio and enhanced renal vascular response to angiotensin II due to hypertrophy and reduced inner radius of smooth-muscle afferent arterioles. Considerable reduction in glomerular filtration rate combined with increased resistance to tissue liquid flow and less pronounced changes in renal flow suggests increased fluid elimination via arteriolovenous shunts at the stage of stable hypertension. The established renal vascular transformation may be needed to maintain high arterial blood pressure during stable hypertension.
用添加了明胶醇的台氏液灌注自发性高血压大鼠的肾脏，结果显示，随着动脉高血压的发展和稳定，肾血管的结构变化逐渐出现，这表现为“灌注压 - 灌注率”曲线和“肾小球滤过率 - 灌注压”曲线的偏移、入球/出球小动脉阻力比增加以及由于平滑肌入球小动脉肥大和内径减小导致的肾血管对血管紧张素II的反应增强。肾小球滤过率显著降低，同时对组织液流动的阻力增加，肾血流量变化不太明显，这表明在稳定高血压阶段，通过动静脉分流增加了液体清除。在稳定高血压期间，可能需要已确立的肾血管转变来维持高动脉血压。
