Stefani F H, Gutzeit K
Klin Monbl Augenheilkd. 1983 Mar;182(3):229-31. doi: 10.1055/s-2008-1054751.
A newly developed choroidal tumor was observed by an ophthalmologist in 1946. Clinically, it was obviously a malignant melanoma and showed signs of growth. The patient, a 57 year-old woman, refused enucleation because her vision was good. She was examined at intervals by her ophthalmologist. Ten years later the tumor had attained a prominence of 18 D and shortly afterwards the patient developed visual disturbances. Another 11 years later vitreous opacities occurred. After a further 5 years the patient presented with glaucoma which led to chronic corneal edema. The eye was finally enucleated in 1977. Now, four years later, the patient is still well and without any sign of metastases. Histopathologic examination revealed a melanoma of spindle-cell type A, measuring 16 X 16 X 16 mm. The tumor had infiltrated the proximal optic fascicle and the overlying retina. As most prognostic data are based on histopathologic findings it seems essential for the future to find out more about the untreated melanomas (growth rate, vascularization, secondary changes such as perifocal inflammatory reactions, lesions of the retinal pigment epithelium barrier, retinal detachment, cyclitis and glaucoma).
1946年，一位眼科医生发现了一例新出现的脉络膜肿瘤。临床上，它显然是恶性黑色素瘤且有生长迹象。患者是一名57岁女性，因视力尚好而拒绝眼球摘除术。她的眼科医生定期对其进行检查。10年后，肿瘤隆起度达到18D，不久后患者出现视觉障碍。又过了11年，玻璃体混浊出现。再过5年后，患者出现青光眼并导致慢性角膜水肿。最终，患眼于1977年被摘除。如今，4年后，患者状况良好，无任何转移迹象。组织病理学检查显示为A型梭形细胞黑色素瘤，大小为16×16×16mm。肿瘤已浸润至近端视束及上方视网膜。由于大多数预后数据基于组织病理学发现，所以未来有必要进一步了解未经治疗的黑色素瘤（生长速度、血管形成、继发性改变，如病灶周围炎症反应、视网膜色素上皮屏障损害、视网膜脱离、睫状体炎和青光眼）。
