Bailey D N
J Anal Toxicol. 1983 Mar-Apr;7(2):76-8. doi: 10.1093/jat/7.2.76.
During toxicology screening of human biological fluids, 4-aminoantipyrine (4-AAP) was detected in 19 patients and identified by two-dimensional TLC and UV spectrophotometry with whole blood concentrations of 4-AAP ranging from 0.4 to greater than 4.9 mg/dL. Of the 19 patients, 15 had received prior treatment at a Mexican health-care facility before transfer to this medical center. Since 4-AAP is a known metabolite of aminopyrine, it is likely that the patients had ingested this anti-inflammatory, analgesic agent in Mexico; however, the clinical histories in this respect were vague. Recognition of the presence of 4-AAP in biological fluids is important, since the parent drug may produce fatal agranulocytosis and the compound may complicate the detection of other compounds that simultaneously partition into the weak-base fraction in toxicology screening.
在对人体生物体液进行毒理学筛查期间，在19名患者中检测到了4-氨基安替比林（4-AAP），并通过二维薄层色谱法和紫外分光光度法进行了鉴定，全血中4-AAP的浓度范围为0.4至大于4.9mg/dL。在这19名患者中，有15名在转至该医疗中心之前曾在墨西哥的一家医疗保健机构接受过治疗。由于4-AAP是氨基比林的已知代谢产物，这些患者很可能在墨西哥摄入了这种抗炎、镇痛药；然而，这方面的临床病史并不明确。认识到生物体液中存在4-AAP很重要，因为母体药物可能会导致致命的粒细胞缺乏症，并且该化合物可能会使在毒理学筛查中同时分配到弱碱部分的其他化合物的检测变得复杂。
