Behrens M I, Soza M A, Inestrosa N C
Muscle Nerve. 1983 Feb;6(2):154-9. doi: 10.1002/mus.880060212.
The chronic administration of nafenopin, a hypolipidemic drug, induced an increase in catalase and acyl-CoA oxidase activities in various skeletal muscles, including the gracilis, diaphragm, soleus, and extensor digitorum longus. The magnitude of the increase was around 100% for both enzymes in each of the muscles studied in spite of the different basal level. These changes seem to be specific of the peroxisomal enzymes because acetylcholinesterase, which is not peroxisomal, did not follow the same pattern in all the muscles. Concomitant with the increase in muscle peroxisomal enzymes, the skeletal muscles presented an altered electromyogram with prolonged insertional activity, repetitive firing of action potentials, and myotonic runs characteristic of myotonia. Our results suggest a role for peroxisomes in the myotonic disorder.
长期服用降血脂药物萘苯丁酸可使包括股薄肌、膈肌、比目鱼肌和趾长伸肌在内的各种骨骼肌中的过氧化氢酶和酰基辅酶A氧化酶活性增加。尽管基础水平不同，但在所研究的每块肌肉中，这两种酶的增加幅度均约为100%。这些变化似乎是过氧化物酶体酶所特有的，因为非过氧化物酶体的乙酰胆碱酯酶在所有肌肉中并未呈现相同的模式。伴随骨骼肌过氧化物酶体酶的增加，骨骼肌的肌电图出现改变，插入活动延长、动作电位重复发放以及呈现肌强直特征性的肌强直放电。我们的结果表明过氧化物酶体在肌强直障碍中起作用。
