Pryor G T, Dickinson J, Howd R A, Rebert C S
Neurobehav Toxicol Teratol. 1983 Jan-Feb;5(1):47-52.
Using several behavioral and neurophysiologic tests, we examined the effects of subchronic inhalation exposure of rats to toluene and compared them with the effects of the known neurotoxicant hexane. The rats were exposed to toluene (900 and 1400 ppm) or hexane (2000 ppm) 14 hr/day, 7 days/week for 14 weeks. Both solvents inhibited weight gain. Hexane caused a neurotoxic syndrome characterized by reductions of grip strength (especially hindlimb), motor activity, and startle responses, and increased latencies of several evoked potential components. Initial acquisition of a conditioned avoidance response (CAR) was also impaired, but subsequent performance was intact. Toluene did not cause the peripheral motor symptoms associated with exposure to hexane. However, a component of the brainstem auditory-evoked response was depressed and CAR acquisition was impaired along with the acquisition of a tone-intensity discrimination task when tested within hours after the daily exposure ended.
我们采用多种行为学和神经生理学测试方法，研究了大鼠亚慢性吸入甲苯的影响，并将其与已知神经毒物己烷的影响进行比较。大鼠每天14小时、每周7天暴露于甲苯（900和1400 ppm）或己烷（2000 ppm）中，持续14周。两种溶剂均抑制体重增加。己烷引起一种神经毒性综合征，其特征为握力（尤其是后肢）、运动活动和惊吓反应降低，以及多个诱发电位成分的潜伏期延长。条件性回避反应（CAR）的初始习得也受损，但随后的表现正常。甲苯未引起与己烷暴露相关的外周运动症状。然而，在每日暴露结束后的数小时内进行测试时，脑干听觉诱发电位的一个成分受到抑制，CAR习得以及音调强度辨别任务的习得均受损。
