7,8-二氯-1,2,3,4-四氢异喹啉对大鼠脑内单胺氧化酶体内抑制作用的证据。
Evidence for inhibition of monoamine oxidase in vivo in rat brain by 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline.
作者信息
Fuller R W, Hemrick-Luecke S K
出版信息
Res Commun Chem Pathol Pharmacol. 1983 Mar;39(3):519-22.
PMID:6856953
Abstract
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (DCTQ) (50 mg/kg i.p.) antagonized the inactivation of MAO by pargyline as measured by direct enzyme assays in brain homogenates and by accumulation of hypothalamic catecholamines. These findings lend credence to the earlier interpretation that changes in brain concentrations of biogenic amines and their metabolites in DCTQ-treated rats were due at least in part to MAO inhibition.
摘要
7,8-二氯-1,2,3,4-四氢异喹啉（DCTQ）（腹腔注射50毫克/千克）可拮抗帕吉林对单胺氧化酶（MAO）的失活作用，这一作用通过脑匀浆中的直接酶测定以及下丘脑儿茶酚胺的积累来衡量。这些发现支持了早期的解释，即DCTQ处理的大鼠脑中生物胺及其代谢物浓度的变化至少部分归因于MAO抑制。
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