Jasmin G, Proschek L
Adv Myocardiol. 1983;4:45-53. doi: 10.1007/978-1-4757-4441-5_3.
It was previously shown that beta-adrenergic blockers exert a protective action on the development of heart necrotic changes in cardiomyopathic hamsters. To further investigate the possible role of catecholamines in the pathogenesis of the hamster hereditary cardiomyopathy, the ventricular adrenergic nerve terminals were visualized by fluorescence histochemistry, and NE uptake and turnover were determined after i.v. injection of labeled NE. It was found that the fluorescent nerve endings strongly proliferate with the occurrence of heart necrotic changes. With healing of the myocardial lesions, the difference between control and myopathic hearts is less apparent, and NE nerve endings are literally absent in the terminal stage of the disease. There was a marked increase in NE uptake during the necrotic stage and, at the same time, a considerable rise in elimination rate constant with a maximum level at terminal state, suggesting that the NE turnover is related to the progression of the disease. In light of the present findings, it can be surmised that NE plays a permissive role in the genesis of the hamster disease by promoting the heart necrotic changes.
先前的研究表明，β-肾上腺素能阻滞剂对心肌病仓鼠心脏坏死性改变的发展具有保护作用。为了进一步研究儿茶酚胺在仓鼠遗传性心肌病发病机制中的可能作用，通过荧光组织化学观察心室肾上腺素能神经末梢，并在静脉注射标记的去甲肾上腺素后测定去甲肾上腺素的摄取和周转率。结果发现，随着心脏坏死性改变的出现，荧光神经末梢强烈增殖。随着心肌病变的愈合，对照心脏与病变心脏之间的差异不太明显，并且在疾病的终末期几乎没有去甲肾上腺素神经末梢。在坏死阶段去甲肾上腺素摄取显著增加，同时消除速率常数大幅上升，在终末期达到最高水平，这表明去甲肾上腺素的周转率与疾病的进展有关。根据目前的研究结果，可以推测去甲肾上腺素通过促进心脏坏死性改变在仓鼠疾病的发生中起允许作用。
