氟对大鼠胶原蛋白合成的影响。

Effect of fluoride on collagen synthesis in the rat.

作者信息

Uslu B

出版信息

Res Exp Med (Berl). 1983;182(1):7-12. doi: 10.1007/BF01852281.

Abstract

Thirty-six young rats were used to determine the effect of the fluoride on collagen synthesis in healing of fracture. Eighteen rats received 100 ppm fluoride per day, the other 18 were not given fluoride and were used as controls. Then the tibiae of the 36 rats were successively fractured and the animals killed. That is, the first 14 animals of either group were killed one a day, and then the remaining four animals were killed on days 21, 28, 35, and 45 as the tibiae were fractured. Collagen synthesis of the callus was examined histochemically and histologically. In the fluoride-treated group, collagen synthesis was found to be defective, while it was normal in the controls.

摘要

36只幼鼠被用于确定氟对骨折愈合中胶原蛋白合成的影响。18只大鼠每天接受100 ppm的氟，另外18只不给予氟作为对照。然后将36只大鼠的胫骨依次骨折并处死动物。也就是说，每组的前14只动物每天处死1只，然后在第21、28、35和45天处死其余4只动物，因为胫骨已骨折。对骨痂的胶原蛋白合成进行组织化学和组织学检查。在氟处理组中，发现胶原蛋白合成存在缺陷，而对照组则正常。