Valbonesi M, Garelli S, Montani F, Mosconi L, Beltramelli A, Zerbi D, Sardella M
Ric Clin Lab. 1983 Jan-Mar;13(1):75-84. doi: 10.1007/BF02904748.
This paper summarizes experience with plasma-exchange therapy for neurological diseases at the Saronno hospital. Most treatments were performed by discontinuous flow centrifugation, but membrane plasma separation and cascade filtration were also employed. Eighty-five patients with demyelinating diseases of the peripheral nervous system (Guillain-Barré syndrome, immune complex polyneuropathies, paraneoplastic polyneuropathies), demyelinating diseases of the central nervous system (multiple sclerosis, subacute sclerosing panencephalitis), dermatopolymyositis and myasthenia gravis have been treated so far. Particular attention is paid to the combination of plasmapheresis with lymphocytapheresis and immunosuppressive drugs. This therapeutic approach appears to bring about dramatic and sustained improvement in most patients with neurological diseases, thus altering their natural course.
本文总结了萨罗诺医院采用血浆置换疗法治疗神经系统疾病的经验。大多数治疗采用间断流动离心法进行，但也采用了膜血浆分离和级联过滤。到目前为止，已经治疗了85例患有周围神经系统脱髓鞘疾病（格林-巴利综合征、免疫复合物性多神经病、副肿瘤性多神经病）、中枢神经系统脱髓鞘疾病（多发性硬化症、亚急性硬化性全脑炎）、皮肌炎和重症肌无力的患者。特别关注血浆置换与淋巴细胞去除术和免疫抑制药物的联合应用。这种治疗方法似乎能使大多数神经系统疾病患者得到显著且持续的改善，从而改变其自然病程。
