Piccoli F, Cillino S, Guarneri R, Ponte F
Riv Neurol. 1983 Jan-Feb;53(1):34-49.
The authors submitted to alloxan hyperglycemia albino rats of the Wistar strain. Alloxan is a sulphydryl poison, characterized by its selective action on the beta-cells of the islets of Langerhans. Rats were partly treated with a mixture of gangliosides both for 10 days before hyperglycemia induction and during the following experimental period. Treatment with gangliosides caused in both groups a precocious and significant normalization of metabolic variation seen in hyperglycemic non treated rats. The Authors discuss the physiopathologic significance of the enzymatic variations found in two nervous structures, retina and sciatic nerve, in which initial diabetes-like condition has been induced. Gangliosides, whose use is warranted by recent studies about their effect in cell membrane function, seem to suggest, in this case, a preeminent metabolic action, also if their role is still not completely clear.
作者将Wistar品系的白化大鼠制成四氧嘧啶性高血糖模型。四氧嘧啶是一种巯基毒物，其特点是对胰岛的β细胞有选择性作用。在诱导高血糖前10天以及随后的实验期间，大鼠均接受神经节苷脂混合物的部分治疗。神经节苷脂治疗使两组中未治疗的高血糖大鼠出现的代谢变化提前并显著恢复正常。作者讨论了在视网膜和坐骨神经这两种神经结构中发现的酶变化的病理生理意义，其中已诱导出初始糖尿病样状态。神经节苷脂因其对细胞膜功能的作用的近期研究而被认为有应用价值，在这种情况下似乎表明其具有卓越的代谢作用，尽管其作用仍不完全清楚。
