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[一组有代表性的住院抑郁症患者的临床特征]

[Clinical characteristics of a representative group of hospitalized depressed patients].

作者信息

Schöpf J, Gaillard J M, Müller C, van Duyse C, Le P K

出版信息

Schweiz Arch Neurol Neurochir Psychiatr. 1983;132(1):131-48.

PMID:6857162
Abstract

In order to define some principal clinical characteristics of the hospitalised depressives, the authors have examined a group of 100 depressed patients consecutively admitted to the Psychiatric University Clinic of Lausanne. The clinic is at the same time a sector hospital. The depressives constituted 21% of all hospitalised patients. The number of depressives admitted during the duration of the study (6 months) permitted to calculate a hospitalisation rate of 86 patients per 100 000 inhabitants and per year. The 100 patients were subclassified in patients with a short depressive reaction, neurotic depressives, and endogenous depressives. Each of the 3 subgroups had about the same size. A modified version of the ICD 9 was used for the diagnostic classification. As a whole, the patients showed serious psychiatric manifestations and the majority presented suicidal tendencies. Besides, there were found characteristics which are not considered to be associated with depressions in general: an elevated proportion of unmarried persons in the total group, psychopathic traits among the reactive and neurotic depressives, and a considerable proportion of parental loss in early childhood in these two last mentioned subgroups. Furthermore, an accumulation of chronic and therapy resistant cases was observed in the group of neurotic depressives. A third of the endogenous depressives had been resistant to the ambulatory antidepressive treatment; a part of these patients responded well to the treatment in the hospital.

摘要

为了明确住院抑郁症患者的一些主要临床特征,作者对连续入住洛桑大学精神病诊所的100名抑郁症患者进行了检查。该诊所同时也是一家区级医院。抑郁症患者占所有住院患者的21%。在研究期间(6个月)收治的抑郁症患者数量,使得每10万居民每年的住院率可计算为86例。这100名患者被分为短期抑郁反应患者、神经症性抑郁症患者和内源性抑郁症患者。3个亚组的规模大致相同。诊断分类采用了修改后的《国际疾病分类第9版》。总体而言,患者表现出严重的精神症状,且大多数有自杀倾向。此外,还发现了一些一般不被认为与抑郁症相关的特征:总群体中未婚者比例较高,反应性和神经症性抑郁症患者中有精神病性特质,以及后两个亚组中相当比例的人在幼儿期经历过父母丧亡。此外,在神经症性抑郁症患者组中观察到慢性和难治性病例的聚集。三分之一的内源性抑郁症患者对门诊抗抑郁治疗有抵抗;其中一部分患者在住院治疗中反应良好。

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