Ott M G, Skory L K, Holder B B, Bronson J M, Williams P R
Scand J Work Environ Health. 1983;9 Suppl 1:1-38.
General study design and environmental considerations. Scand j work environ health 9 (1983): suppl 1, 1-7. Recent concern regarding health hazards of methylene chloride stem primarily from the discovery of its metabolism to carboxyhemoglobin. In this report, a research program is described, the purpose of which was to assess potential health effects of methylene chloride exposure in an occupational setting. Particular attention was given to evaluating possible direct and carboxyhemoglobin-mediated effects on the hematopoietic and circulatory systems. The study involved one fiber production plant which used a methylene chloride/methanol mixture and acetone as solvents and a second fiber production plant that used acetone only. The research design included a retrospective cohort mortality study and several health evaluation studies, as well as an environmental assessment of the two plants. Industrial hygiene monitoring indicated that typical methylene chloride exposures ranged from an 8-h time-weighted average of 140 ppm in areas of low methylene chloride use to a corresponding average of 475 ppm in areas of high methylene chloride use and that methanol was present in about a one to ten ratio to methylene chloride. Acetone exposures in both plants ranged from 100 to over 1,000 ppm (time-weighted average).
一般研究设计及环境因素。《斯堪的纳维亚工作环境与健康杂志》9（1983年）：增刊1，第1 - 7页。近期对二氯甲烷健康危害的关注主要源于发现其可代谢生成碳氧血红蛋白。在本报告中，描述了一项研究计划，其目的是评估职业环境中二氯甲烷暴露可能产生的健康影响。特别关注评估对造血系统和循环系统可能的直接影响以及由碳氧血红蛋白介导的影响。该研究涉及一家使用二氯甲烷/甲醇混合物和丙酮作为溶剂的纤维生产厂，以及另一家仅使用丙酮的纤维生产厂。研究设计包括一项回顾性队列死亡率研究、多项健康评估研究以及对这两家工厂的环境评估。工业卫生监测表明，典型的二氯甲烷暴露范围从二氯甲烷使用量低的区域8小时时间加权平均浓度140 ppm到二氯甲烷使用量高的区域相应平均浓度475 ppm，且甲醇与二氯甲烷的比例约为1比10。两家工厂中的丙酮暴露范围为100至超过1000 ppm（时间加权平均）。
