Weber W, von Essen C F, Metzger U, Stalder G A
Schweiz Med Wochenschr. 1983 Mar 26;113(12):417-26.
The prognosis of pancreatic adenocarcinoma is still very poor. Research activities have, however, been instituted recently in all fields. Epidemiologic studies indicate etiologic roles of diabetes mellitus, smoking, and meat and coffee consumption. Sonography of the pancreas is at present the best screening method. The significance of computerized tomography, endoscopic retrograde cholangiopancreatography (ERCP), arteriography and tumor markers is discussed. A TNM staging system and prognostic factors are presented. Resection is the treatment of choice for organ-limited pancreatic cancer. The development of new radiation modalities (e.g. pi-mesons) promises improved loco-regional tumor control. The most effective chemotherapy consists of combinations containing 5-fluorouracil, adriamycin and mitomycin-C. Intensive future research in the field of pancreatic cancer is essential if the prognosis of this devastating disease is to be improved.
胰腺腺癌的预后仍然很差。然而，最近在各个领域都开展了研究活动。流行病学研究表明糖尿病、吸烟以及肉类和咖啡的摄入在病因方面所起的作用。目前，胰腺超声检查是最佳的筛查方法。文中讨论了计算机断层扫描、内镜逆行胰胆管造影（ERCP）、动脉造影和肿瘤标志物的意义。介绍了TNM分期系统和预后因素。手术切除是局限性胰腺癌的首选治疗方法。新的放射治疗方式（如π介子）的发展有望改善局部肿瘤控制。最有效的化疗方案是包含5-氟尿嘧啶、阿霉素和丝裂霉素-C的联合用药。如果要改善这种毁灭性疾病的预后，未来在胰腺癌领域开展深入研究至关重要。
