Man E H, Sandhouse M E, Burg J, Fisher G H
Science. 1983 Jun 24;220(4604):1407-8. doi: 10.1126/science.6857259.
An age-related accumulation of D-aspartic acid was detected in the white matter of ten normal brains from individuals aged 30 to 80 years. Gray matter showed no systematic increase in D-aspartic acid. The rate constant for D-aspartate formation in the brain is equal to the predicted value calculated for 37 degrees C. Accumulation of the uncommon D-aspartate isomer in myelinated white matter implies that there is little or no turnover of this tissue, and this may have a bearing on dysfunction of the aging brain or on other diseases of myelin.
在30至80岁的10个正常大脑的白质中检测到与年龄相关的D-天冬氨酸积累。灰质中D-天冬氨酸没有系统性增加。大脑中D-天冬氨酸形成的速率常数等于在37摄氏度下计算出的预测值。有髓白质中不常见的D-天冬氨酸异构体的积累意味着该组织几乎没有或没有更新，这可能与衰老大脑的功能障碍或其他髓鞘疾病有关。
