Green D, Ts'ao C H
Thromb Res. 1983 Feb 15;29(4):403-6. doi: 10.1016/0049-3848(83)90243-8.
The effect of warfarin-induced factor VII deficiency on the skin bleeding time was investigated in 10 consecutive patients with mean prothrombin times of 33 sec and factor VII levels of 7%. Bleeding times in all but one subject were entirely within the normal range. We conclude that warfarin administration, even to the point of prolonging the prothrombin time beyond the therapeutic range, is not associated with an abnormal bleeding time. Furthermore, from the above evidence and a review of the literature, it is considered doubtful that factor VII plays a major role in primary hemostasis.
对10例连续患者进行了研究，这些患者的平均凝血酶原时间为33秒，因子VII水平为7%，以探讨华法林诱导的因子VII缺乏对皮肤出血时间的影响。除1例患者外，所有患者的出血时间均完全在正常范围内。我们得出结论，即使华法林的使用将凝血酶原时间延长至超出治疗范围，也不会导致出血时间异常。此外，根据上述证据及文献综述，认为因子VII在初级止血中起主要作用这一观点值得怀疑。
