一种开放式大鼠气管植入模型：甲醛对呼吸道上皮的毒性作用。

An open-ended rat tracheal implant model: toxic effects of formaldehyde on the respiratory epithelium.

作者信息

Shiba M, Marchok A C, Klein-Szanto A J

出版信息

Toxicol Lett. 1983 May;16(3-4):241-8. doi: 10.1016/0378-4274(83)90183-2.

Abstract

An open-ended rat tracheal implant model was developed to permit quantitative and repetitive exposure of respiratory epithelia to test substances of a variety of physical forms. To investigate the acute toxicity of formaldehyde with this new model, tracheas were exposed to formaldehyde solutions twice a week, for up to 12 weeks. At the higher formaldehyde concentrations (1.0, 0.6, 0.3%) the tracheal lumens became obstructed by granulation tissue. At the lower concentrations (0.2, 0.1, 0.01%), the appearance of flattened and atrophic epithelium as well as hyperplasia and squamous metaplasia were observed. The extent of these epithelial alterations was, for the most part, formaldehyde dose-dependent.

摘要

开发了一种开放式大鼠气管植入模型，以允许将呼吸道上皮定量且重复地暴露于各种物理形式的测试物质中。为了用这个新模型研究甲醛的急性毒性，每周两次将气管暴露于甲醛溶液中，持续长达12周。在较高的甲醛浓度（1.0%、0.6%、0.3%）下，气管腔被肉芽组织阻塞。在较低浓度（0.2%、0.1%、0.01%）下，观察到扁平萎缩上皮的出现以及增生和鳞状化生。这些上皮改变的程度在很大程度上与甲醛剂量有关。