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Isolation and amino acid compositions of geographutoxin I and II from the marine snail Conus geographus.

作者信息

Nakamura H, Kobayashi J, Ohizumi Y, Hirata Y

出版信息

Experientia. 1983 Jun 15;39(6):590-1. doi: 10.1007/BF01971110.

DOI:10.1007/BF01971110
PMID:6857761
Abstract

The peptide toxins having inhibitory effects on the contractile response of the mouse diaphragm to direct stimulation, geographutoxin I and II, have been isolated from Conus geographus, and their amino acid compositions have been determined.

摘要

相似文献

1
Isolation and amino acid compositions of geographutoxin I and II from the marine snail Conus geographus.
Experientia. 1983 Jun 15;39(6):590-1. doi: 10.1007/BF01971110.
2
The amino acid sequences of homologous hydroxyproline-containing myotoxins from the marine snail Conus geographus venom.来自海洋蜗牛地纹芋螺毒液中同源含羟脯氨酸肌毒素的氨基酸序列。
FEBS Lett. 1983 May 8;155(2):277-80. doi: 10.1016/0014-5793(82)80620-0.
3
Disulfide pairings in geographutoxin I, a peptide neurotoxin from Conus geographus.
FEBS Lett. 1990 May 7;264(1):29-32. doi: 10.1016/0014-5793(90)80756-9.
4
Isolation and structure of a peptide toxin from the marine snail Conus magus.
Arch Biochem Biophys. 1982 Oct 1;218(1):329-34. doi: 10.1016/0003-9861(82)90351-4.
5
Geographutoxin II, a novel peptide inhibitor of Na channels of skeletal muscles and autonomic nerves.地理毒素II，一种新型的骨骼肌和自主神经钠通道肽抑制剂。
J Pharmacol Exp Ther. 1986 Oct;239(1):243-8.
6
Presynaptic inhibitory effect of geographutoxin II, a new peptide toxin from Conus geographus venom, in the guinea-pig vas deferens.地纹芋螺毒素II（一种来自地纹芋螺毒液的新型肽毒素）对豚鼠输精管的突触前抑制作用。
Eur J Pharmacol. 1986 Jan 21;120(2):245-8. doi: 10.1016/0014-2999(86)90548-0.
7
Peptide toxins from Conus geographus venom.地纹芋螺毒液中的肽类毒素。
J Biol Chem. 1981 May 25;256(10):4734-40.
8
Preferential block of skeletal muscle sodium channels by geographutoxin II, a new peptide toxin from Conus geographus.
Pflugers Arch. 1986 Aug;407(2):241-3. doi: 10.1007/BF00580684.
9
Characterization of the neurotoxic constituents of Conus geographus (L) venom.地纹芋螺（Conus geographus (L)）毒液神经毒性成分的表征
Life Sci. 1977 Dec 15;21(12):1759-69. doi: 10.1016/0024-3205(77)90156-4.
10
Occurrence of hydroxyproline in a toxin from the marine snail Conus geographus.
Arch Biochem Biophys. 1982 Jul;216(2):765-7. doi: 10.1016/0003-9861(82)90268-5.

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Novel interactions identified between micro -Conotoxin and the Na+ channel domain I P-loop: implications for toxin-pore binding geometry.微芋螺毒素与钠离子通道结构域I的P环之间新发现的相互作用：对毒素-孔结合几何结构的影响
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3
E.E. Just Lecture, 1996. Conus venom peptides, receptor and ion channel targets, and drug design: 50 million years of neuropharmacology.

本文引用的文献

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Cone shell stings; recent cases of human injury due to venomous marine snails of the genus Conus.
Hawaii Med J. 1958 Jul-Aug;17(6):528-32.
2
Pharmacological study on the venom of the marine snail Conus textile.
Toxicon. 1981;19(6):757-62. doi: 10.1016/0041-0101(81)90072-6.
3
Effect of venoms from Conidae on skeletal, cardiac and smooth muscles.
Toxicon. 1982;20(5):823-30. doi: 10.1016/0041-0101(82)90069-1.
4
Peptide toxins from Conus geographus venom.地纹芋螺毒液中的肽类毒素。
1996年E.E.贾斯特讲座。芋螺毒液肽、受体和离子通道靶点以及药物设计：五千万年的神经药理学
Mol Biol Cell. 1997 Nov;8(11):2101-9. doi: 10.1091/mbc.8.11.2101.
4
Pore residues critical for mu-CTX binding to rat skeletal muscle Na+ channels revealed by cysteine mutagenesis.通过半胱氨酸诱变揭示对μ-CTX与大鼠骨骼肌钠通道结合至关重要的孔道残基。
Biophys J. 1997 Oct;73(4):1874-84. doi: 10.1016/S0006-3495(97)78218-3.
5
[Venomous animals and their venoms].[有毒动物及其毒液]
Naturwissenschaften. 1986 Aug;73(8):459-70. doi: 10.1007/BF00367191.
6
Geographutoxin-sensitive and insensitive sodium currents in mouse skeletal muscle developing in situ.原位发育的小鼠骨骼肌中对地理毒素敏感和不敏感的钠电流。
J Physiol. 1989 Jul;414:159-77. doi: 10.1113/jphysiol.1989.sp017682.
7
Use of geographutoxin II (mu-conotoxin) for the study of neuromuscular transmission in mouse.使用地理毒素II（μ-芋螺毒素）研究小鼠神经肌肉传递。
Br J Pharmacol. 1989 Jul;97(3):934-40. doi: 10.1111/j.1476-5381.1989.tb12034.x.
8
Preferential block of skeletal muscle sodium channels by geographutoxin II, a new peptide toxin from Conus geographus.
Pflugers Arch. 1986 Aug;407(2):241-3. doi: 10.1007/BF00580684.
9
Conotoxin GIIIA: selective inhibition of 22Na influx via voltage-dependent Na channels in adrenal medullary cells.芋螺毒素GIIIA：对肾上腺髓质细胞中电压依赖性钠通道介导的22Na内流具有选择性抑制作用。
Naunyn Schmiedebergs Arch Pharmacol. 1990 Sep;342(3):323-7. doi: 10.1007/BF00169444.
J Biol Chem. 1981 May 25;256(10):4734-40.
5
Peptides isolated from the venom of Conus geographus block neuromuscular transmission.从地纹芋螺毒液中分离出的肽可阻断神经肌肉传导。
Neurosci Lett. 1981 Aug 7;25(1):57-62. doi: 10.1016/0304-3940(81)90101-4.
6
Pharmacology of the venom of Conus geographus.地纹芋螺毒液的药理学
Toxicon. 1974 Mar;12(2):131-8. doi: 10.1016/0041-0101(74)90236-0.
7
Purification and properties of a myotoxin from Conus geographus venom.地纹芋螺毒液中一种肌毒素的纯化及特性
Arch Biochem Biophys. 1978 Oct;190(2):539-48. doi: 10.1016/0003-9861(78)90308-9.
8
Characterization of the neurotoxic constituents of Conus geographus (L) venom.地纹芋螺（Conus geographus (L)）毒液神经毒性成分的表征
Life Sci. 1977 Dec 15;21(12):1759-69. doi: 10.1016/0024-3205(77)90156-4.