Donhuijsen K, Winkelmeyer M, Hirche H, Leder L D
Zentralbl Allg Pathol. 1983;127(1-2):109-18.
In chronic lymphatic leukemia lymph nodes show very often nodular aggregates of cells that are somewhat larger than small lymphocytes and that are less hyperchromatic and less closely packed. These aggregates appear histologically as light areas that are called pseudofollicles, pseudonodules or proliferation centers. However, it has not been substantiated as yet that a more active proliferation of cells indeed takes place within these areas. Therefore, in 10 cases of chronic lymphatic leukemia the DNA-content, the size of the nuclei, and the frequency of mitoses within and outside the pseudofollicles were assessed. It could be shown that the cells of the pseudofollicles are indeed more actively proliferating populations than the cells outside the pseudofollicles. This proves that pseudofollicles are proliferation centers.
在慢性淋巴细胞白血病中，淋巴结常常显示出细胞的结节状聚集，这些细胞比小淋巴细胞稍大，染色质较少，排列也不那么紧密。这些聚集物在组织学上表现为浅色区域，称为假滤泡、假结节或增殖中心。然而，目前尚未证实这些区域内确实发生了更活跃的细胞增殖。因此，对10例慢性淋巴细胞白血病患者假滤泡内外的DNA含量、细胞核大小和有丝分裂频率进行了评估。结果表明，假滤泡中的细胞确实比假滤泡外的细胞增殖更为活跃。这证明假滤泡是增殖中心。
