Kerbiriou D M, Griffin J H, Larrieu M J
Adv Exp Med Biol. 1983;156:233-40.
Antisera directed against the isolated heavy and light chains of high MW kininogen were used for immunochemical studies of high MW and low MW kininogens. The heavy chain region of high MW kininogen share identical immunologic determinants indicating similar structures. The light chain region of high MW kininogen is immunologically distinct from low MW kininogen and is therefore unique to high MW kininogen. Consequently the anti-heavy chain antibody could be used in radioimmunoassays to quantitate total kininogens antigens, whereas the anti-light chain antibody could be used as specific tool to quantitate high MW kininogen.
针对高分子量激肽原分离出的重链和轻链的抗血清，用于高分子量和低分子量激肽原的免疫化学研究。高分子量激肽原的重链区域具有相同的免疫决定簇，表明结构相似。高分子量激肽原的轻链区域在免疫上与低分子量激肽原不同，因此是高分子量激肽原所特有的。因此，抗重链抗体可用于放射免疫测定以定量总激肽原抗原，而抗轻链抗体可作为定量高分子量激肽原的特异性工具。
