McHale P A, Rembert J C, Greenfield J C
Am J Cardiol. 1983 Jun;51(10):1722-7. doi: 10.1016/0002-9149(83)90218-7.
This study was undertaken to examine the independent effects of atrial tachycardia, ventricular tachycardia, and atrial fibrillation (AF) on atrial and ventricular blood flow in conscious, heart-blocked dogs using radioactive microspheres. Atrial blood flow averaged 0.54 +/- 0.08 ml/min/g during the control period at an atrial rate of 124 beats/min and a ventricular rate of 90 beats/min. Atrial flow increased to 0.72 +/- 0.12 ml/min/g during atrial pacing at 236 beats/min, but was not significantly altered by ventricular pacing at 200 beats/min. AF at a ventricular rate of 90 beats/min resulted in atrial flow values of 0.91 +/- 0.08 ml/min/g. The ratio of atrial flow to left ventricular flow during AF averaged 1.18 +/- 0.08. Administration of a maximal vasodilating dose of adenosine during AF further increased atrial flow to 2.18 +/- 0.16 ml/min/g. Atrial tachycardia or AF did not significantly affect ventricular blood flow. These data indicate (1) that atrial blood flow increases significantly during AF, reaching flow values per gram of tissue comparable to those of the left ventricle, and (2) that this flow is regulated by the metabolic needs of the atrial tissue and does not represent maximal vasodilation.
本研究旨在利用放射性微球，研究房性心动过速、室性心动过速和心房颤动（AF）对清醒、心脏传导阻滞犬心房和心室血流的独立影响。在对照期，心房率为124次/分钟，心室率为90次/分钟时，心房血流平均为0.54±0.08毫升/分钟/克。在以236次/分钟进行心房起搏时，心房血流增加至0.72±0.12毫升/分钟/克，但在以200次/分钟进行心室起搏时，心房血流无显著变化。心室率为90次/分钟的房颤导致心房血流值为0.91±0.08毫升/分钟/克。房颤期间心房血流与左心室血流的比值平均为1.18±0.08。在房颤期间给予最大剂量的血管扩张剂腺苷，可使心房血流进一步增加至2.18±0.16毫升/分钟/克。房性心动过速或房颤对心室血流无显著影响。这些数据表明：（1）房颤期间心房血流显著增加，每克组织的血流值与左心室相当；（2）这种血流受心房组织代谢需求的调节，并非最大程度的血管扩张。
