Danielides I C, Constantoulakis M, Daikos G K
Am J Gastroenterol. 1983 Jun;78(6):378-80.
Hepatitis developed in two patients treated with high doses (1000 mg/day) of isoniazid for severe tuberculous meningitis. Isoniazid was discontinued and later readministered in gradually increasing intrathecal and subsequently oral doses, up to the final dose of 400 mg/day. Transaminases remained normal, during 12 months on this dose, suggesting dose dependence of hepatotoxicity or a metabolic adaptation to the injury. Continued isoniazid treatment can be important in similar cases and it may become possible, if oral or intrathecal doses significantly lower than the initial hepatotoxic ones, are used.
两名因严重结核性脑膜炎接受高剂量（1000毫克/天）异烟肼治疗的患者发生了肝炎。停用异烟肼后，随后以逐渐增加的鞘内注射剂量，继而口服给药，直至最终剂量400毫克/天重新给药。在此剂量下治疗12个月期间，转氨酶保持正常，提示肝毒性存在剂量依赖性或对损伤的代谢适应。在类似病例中，继续使用异烟肼治疗可能很重要，如果使用明显低于最初引起肝毒性的口服或鞘内注射剂量，或许是可行的。
