Kramer P H, Imboden J B, Waldman F M, Turley K, Ports T A
Am J Med. 1983 Jun;74(6):1088-91. doi: 10.1016/0002-9343(83)90825-2.
Valvular heart disease is rare in patients with juvenile chronic arthritis. We describe a 27-year-old woman with the systemic-onset form of juvenile chronic arthritis in whom aortic insufficiency necessitated valve replacement. Nodules were seen on both the aortic and anterior mitral leaflets at surgery, and histopathologic evaluation of the excised aortic leaflets demonstrated nonspecific changes similar to those described in rheumatoid valve disease causing aortic insufficiency in adults with rheumatoid arthritis. We believe that this is the first reported case of aortic insufficiency in systemic-onset juvenile chronic arthritis in which the pathologic condition of the valve can be attributed to the underlying disease.
青少年慢性关节炎患者中瓣膜性心脏病较为罕见。我们描述了一名27岁患有青少年慢性关节炎全身发病型的女性，其主动脉瓣关闭不全需要进行瓣膜置换。手术中在主动脉瓣和二尖瓣前叶均可见结节，对切除的主动脉瓣叶进行组织病理学评估显示，其非特异性改变与类风湿性瓣膜病中所描述的相似，类风湿性瓣膜病可导致成年类风湿关节炎患者出现主动脉瓣关闭不全。我们认为，这是首例报道的全身发病型青少年慢性关节炎合并主动脉瓣关闭不全的病例，其中瓣膜的病理状况可归因于潜在疾病。
