Rubinstein A, Pierce C E, Bloomgarden Z
Am J Med. 1983 Jul;75(1):161-5. doi: 10.1016/0002-9343(83)91182-8.
Two patients with inadequately controlled diabetes mellitus had chronic foot ulcers that were refractory to repeated attempts with conventional treatment. In both patients, complete healing of the foot lesions occurred six to eight weeks after continuous subcutaneous insulin infusion was instituted and blood sugar levels had become normal. This suggests that good control of diabetes, as obtainable with continuous subcutaneous insulin infusion, stimulates healing of foot ulcers. Possible reasons for this finding are reviewed.
两名糖尿病控制不佳的患者患有慢性足部溃疡，常规治疗多次尝试均无效。在这两名患者中，持续皮下胰岛素输注并使血糖水平恢复正常六至八周后，足部病变完全愈合。这表明，持续皮下胰岛素输注可实现的良好血糖控制能促进足部溃疡的愈合。本文对这一发现的可能原因进行了综述。
