Johnson R B, Low F N
Anat Anz. 1983;153(2):107-18.
Proteoglycans are of interest because of their complex role in the development and maintenance of connective tissues. The present study demonstrates changes in the distribution of proteoglycans in the developing alveolar bone of the mouse using techniques of light and high-voltage electron microscopy. In early development proteoglycans are uniformly distributed throughout the interdental septum. By day 25 there is a loss of proteoglycans, probably as a result of mineralization and the maturation of the collagen of transalveolar fibres. By day 45 proteoglycans are distributed only in tissues adjacent to transalveolar fibres. These proteoglycans occupy the channels surrounding transalveolar fibres and the adjacent bone matrix. It is proposed by the authors that these proteoglycans are involved in the maintenance of the collagen of the transalveolar fibres. Because of the absence of fibroblasts adjacent to transalveolar fibres, proteoglycans are thought to be essential carriers of tropocollagen to these large fibres.
蛋白聚糖因其在结缔组织发育和维持中的复杂作用而备受关注。本研究利用光学显微镜和高压电子显微镜技术，展示了小鼠发育中的牙槽骨中蛋白聚糖分布的变化。在早期发育阶段，蛋白聚糖均匀分布于整个牙间间隔。到第25天时，蛋白聚糖有所减少，这可能是矿化以及经牙槽纤维胶原蛋白成熟的结果。到第45天时，蛋白聚糖仅分布于与经牙槽纤维相邻的组织中。这些蛋白聚糖占据了经牙槽纤维周围的通道以及相邻的骨基质。作者提出，这些蛋白聚糖参与了经牙槽纤维胶原蛋白的维持。由于经牙槽纤维附近不存在成纤维细胞，蛋白聚糖被认为是原胶原蛋白运输到这些大纤维的重要载体。
