[Topochemistry of aminopeptidase A (angiotensinase A) in the kidney cortex of the golden hamster].

The localization of aminopeptidase A (APA; E.C. 3.4.11.7) in the kidney cortex of the golden hamster was demonstrated by histochemical means (simultaneous azo coupling technique; alpha-L-Glu-MNA as substrate and HNF as coupling agent). APA was shown in the renal corpuscle (mainly podocytes and epithelium of the Bowman's capsule), the brush border of the proximal tubule, the perivascular tissue and some peritubular capillaries.--The demonstration of APA in the perivascular tissue of the juxtaglomerular apparatus (JGA) appears to have bearing on the regulation of angiotensin effects in the JGA for APA is an angiotensin degrading enzyme.