用比考扎霉素（CGP 3543/E）治疗急性非寄生虫性腹泻患者肠道菌群的细菌学研究。
Bacteriological studies of the enteric flora of patients treated with bicozamycin (CGP 3543/E) for acute nonparasitic diarrhea.
作者信息
Harford P S, Murray B E, DuPont H L, Ericsson C D
出版信息
Antimicrob Agents Chemother. 1983 Apr;23(4):630-3. doi: 10.1128/AAC.23.4.630.
Abstract
During a therapeutic trial of bicozamycin (BI) for traveler's diarrhea, aerobically grown, gram-negative bacteria, predominantly Escherichia coli, were decreased by 2 to 3 logs per g of stool; the number of BI-resistant gram-negative bacteria did not increase. Resistant species were most often Citrobacter freundii, Klebsiella pneumoniae, and Morganella morganii, and few BI-resistant E. coli strains were isolated. Cross-resistance between BI and other antimicrobial agents was not found. Resistance to BI could not be transferred or mobilized to an E. coli K-12 recipient.
摘要
在一项关于比考扎霉素（BI）治疗旅行者腹泻的试验中，每克粪便中需氧培养的革兰氏阴性菌（主要是大肠杆菌）数量减少了2至3个对数级；对BI耐药的革兰氏阴性菌数量并未增加。耐药菌株最常见的是弗氏柠檬酸杆菌、肺炎克雷伯菌和摩根摩根菌，分离出的对BI耐药的大肠杆菌菌株很少。未发现BI与其他抗菌药物之间存在交叉耐药性。BI的耐药性无法转移或传递给大肠杆菌K-12受体菌。
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