温度诱导的家兔睾丸体外收缩性变化

Temperature-induced alterations in rabbit testicular contractility in vitro.

作者信息

Nemetallah B R, Ellis L C

出版信息

Arch Androl. 1983 May;10(2):161-8. doi: 10.3109/01485018308987558.

Abstract

Rabbit testicular contractions and intratesticular pressure were recorded in vitro as temperature was increased from 33 to 38 degrees C. The response of the testicular capsule to several physiological agents was quantified at 35, 37 and 38 degrees C. A corresponding increase in intratesticular pressure was observed with each contraction. Uniform intratesticular pressures developed in normal spontaneous autorhythmic testicular preparations. The force of capsular contractions increased slightly from 33 to 35 degrees C, but decreased markedly with temperatures above 35 degrees C. Intratesticular pressure increased linearly with increased force of contractions to a maximum of 143 mg of tension. As intratesticular pressure increased, the amplitude of contractions decreased. Marked irregularities in force and frequency of contractions occurred with temperatures above 38 degrees C. Increasing testicular temperature from 35 to 37 degrees C and from 37 to 38 degrees C both markedly reduced the effectiveness of acetylcholine by 58 and 71%, serotonin by 52 and 71%, epinephrine by 41 and 45%, PGF2 alpha by 37 and 54%, histamine by 33 and 54% and bradykinin by 29 and 43%, respectively, in their ability to increase tone of the capsule.

摘要

当温度从33℃升高到38℃时，在体外记录兔睾丸的收缩和睾丸内压力。在35℃、37℃和38℃下，对睾丸白膜对几种生理制剂的反应进行了量化。每次收缩时均观察到睾丸内压力相应升高。在正常的自发性自律性睾丸制剂中出现均匀的睾丸内压力。白膜收缩力在33℃至35℃时略有增加，但在温度高于35℃时显著下降。睾丸内压力随收缩力增加呈线性增加，最大张力为143毫克。随着睾丸内压力增加，收缩幅度减小。在温度高于38℃时，收缩力和频率出现明显不规则。将睾丸温度从35℃升高到37℃以及从37℃升高到38℃，均显著降低了乙酰胆碱、5-羟色胺、肾上腺素、前列腺素F2α、组胺和缓激肽增加白膜张力的能力，其降低幅度分别为58%和71%、52%和71%、41%和45%、37%和54%、33%和54%以及29%和43%。