Ban S, Iida S, Shimba H, Awa A A, Nowak S M, Sugahara T
Biochem Biophys Res Commun. 1983 May 31;113(1):142-7. doi: 10.1016/0006-291x(83)90443-6.
Endoreduplication (ER) could be induced very effectively in Chinese hamster V79 cells exposed to cytosine arabinoside (1-beta-D-arabinofuranosylcytosine; Ara-C). Cells were cultured for 48 hours in Ara-C containing medium. ER frequency increases rapidly after Ara-C release. About 60% of metaphase cells were endoreduplicated at 8-10 hours after release from Ara-C (5 micrograms/ml). Induction of ER also depends on Ara-C concentrations.
