血红蛋白奥尔巴尼 - 佐治亚型或α2(11)(A9)赖氨酸导致β2位天冬酰胺。
Hb Albany-GA or alpha 2(11)(A9)Lys leads to Asn beta 2.
作者信息
Webber B B, Lam H, Wilson J B, Huisman T H
出版信息
Hemoglobin. 1983;7(3):257-62. doi: 10.3109/03630268309048654.
A fast-moving alpha chain abnormal hemoglobin (Hb J) was observed in a black teenager from southern Georgia. Its quantity, i.e. the sum of Hb J and Hb J2, was 23.8%. Its presence did not cause any hematological or clinical abnormalities. Tryptic peptides from a digest of the alpha-J chain were separated by HPLC. Amino acid analysis of these peptides and sequence analysis of the abnormal T-2,3 nonapeptide identified a Lys leads to Asn substitution at position alpha 11(A9).
在一名来自佐治亚州南部的黑人青少年中发现了一种快速移动的α链异常血红蛋白（Hb J）。其含量，即Hb J和Hb J2的总和为23.8%。它的存在未引起任何血液学或临床异常。通过高效液相色谱法分离了α-J链消化产物中的胰蛋白酶肽段。对这些肽段进行氨基酸分析以及对异常的T-2,3九肽进行序列分析，确定在α11（A9）位置发生了赖氨酸到天冬酰胺的替换。
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