Yeh T F, Luken J, Raval D, Thalji A, Carr I, Pildes R S
Br Heart J. 1983 Jul;50(1):27-30. doi: 10.1136/hrt.50.1.27.
An analysis of clinical response and plasma indomethacin concentration was performed on 10 small (less than or equal to 1000 g) and 12 large (greater than 1000 g) premature infants who had symptomatic ductus arteriosus and required intravenous indomethacin therapy (0.3 mg/kg per day). The postnatal age, daily fluid intake, and cardiopulmonary status of the two groups at time of study were comparable, The small premature infants had a significantly lower peak plasma indomethacin concentration and lower concentration in the first four hours after infusion, and lower plasma concentration X time integral than that of the larger premature infants. There was a significant difference between the groups in proportion of response (2/10 vs 9/12) after one dose of indomethacin; this difference was not seen after two to three doses. The results of the study suggest that small premature infants do respond to indomethacin treatment, but compared to the larger infants may require repeated doses.
对10名小早产儿（体重小于或等于1000克）和12名大早产儿（体重大于1000克）进行了临床反应和血浆吲哚美辛浓度分析，这些早产儿患有症状性动脉导管未闭且需要静脉注射吲哚美辛治疗（每天0.3毫克/千克）。研究时两组的出生后年龄、每日液体摄入量和心肺状况具有可比性。小早产儿的血浆吲哚美辛峰值浓度显著较低，输注后前四小时的浓度较低，且血浆浓度×时间积分低于大早产儿。一剂吲哚美辛后两组的反应比例存在显著差异（2/10对9/12）；两到三剂后未观察到这种差异。研究结果表明，小早产儿确实对吲哚美辛治疗有反应，但与较大婴儿相比可能需要重复给药。
