Saarikoski S
Biol Neonate. 1983;43(3-4):158-63. doi: 10.1159/000241623.
The uptake of 3H-NA into human fetal heart tissue was low during the first half of gestation, only one-fifth of that observed in the mouse heart. A gradual increase in uptake was seen during the second trimester of gestation. A drop in temperature resulted in inhibition of 3H-NA uptake in all samples, but most distinctly in the mouse heart and in the human fetal heart at 14-20 weeks of gestation. Cocaine and desipramine reduced the uptake of 3H-NA in human fetal atria after 14 weeks of gestation but not before that. Nialamide showed no such effect. The functional development of the noradrenergic nervous system in the human fetal heart was found to be very slight during the first trimester of pregnancy. After that a gradual maturation of noradrenergic mechanisms was seen. At the end of the first half of gestation the noradrenergic neurons in the human fetal heart may be held to function qualitatively similarly to those in the mature mouse heart.
在妊娠前半期，3H-去甲肾上腺素（3H-NA）进入人胎儿心脏组织的摄取量较低，仅为在小鼠心脏中观察到摄取量的五分之一。在妊娠中期可见摄取量逐渐增加。温度下降导致所有样本中3H-NA摄取受到抑制，但在妊娠14 - 20周时，小鼠心脏和人胎儿心脏中最为明显。可卡因和地昔帕明在妊娠14周后可降低人胎儿心房中3H-NA的摄取，但在此之前无此作用。尼亚酰胺未显示出此类效应。发现人胎儿心脏中去甲肾上腺素能神经系统在妊娠头三个月的功能发育非常轻微。在此之后可见去甲肾上腺素能机制逐渐成熟。在妊娠前半期结束时，人胎儿心脏中的去甲肾上腺素能神经元在功能性质上可能与成熟小鼠心脏中的神经元相似。
