Finley J P, Nugent S T
Can J Physiol Pharmacol. 1983 Apr;61(4):329-35. doi: 10.1139/y83-050.
Periodic breathing is common in normal infants, but may be associated with prolonged apnea leading to crib death. The mechanisms of periodic breathing and its relation to normal breathing patterns are unclear. We recorded respiratory and heart rate (HR) patterns of 11 healthy newborn infants during quiet sleep, in both normal and periodic breathing. Spectral analysis of the respiratory pattern revealed a low-frequency (LF) periodicity in normal breathing approximately equal to the frequency of periodic breathing when this occurs. Periodic breathing thus appears to be an exaggeration of an underlying slow amplitude variation which is present in regular breathing. LF periodicity also appeared in the HR pattern in both normal and periodic breathing, suggesting an LF modulation of cardiovascular control as well. The lack of a definite phase relation between HR and ventilation at LF may indicate dominant peripheral, rather than central, interactions between HR and respiration at these frequencies.
周期性呼吸在正常婴儿中很常见，但可能与导致婴儿猝死的呼吸暂停延长有关。周期性呼吸的机制及其与正常呼吸模式的关系尚不清楚。我们记录了11名健康新生儿在安静睡眠时正常呼吸和周期性呼吸状态下的呼吸和心率（HR）模式。对呼吸模式的频谱分析显示，正常呼吸中存在低频（LF）周期性，其频率与周期性呼吸发生时的频率大致相等。因此，周期性呼吸似乎是正常呼吸中存在的潜在缓慢幅度变化的一种夸张表现。低频周期性在正常呼吸和周期性呼吸的心率模式中也有出现，这表明心血管控制也存在低频调制。低频时心率与通气之间缺乏明确的相位关系，这可能表明在这些频率下，心率与呼吸之间的相互作用主要是外周性的，而非中枢性的。
