Nagahama S, Fujimaki M, Kawabe H, Nakamura R, Saito I, Saruta T
Clin Endocrinol (Oxf). 1983 Mar;18(3):287-93. doi: 10.1111/j.1365-2265.1983.tb03213.x.
The aim of this study was to determine the effect of metoclopramide, a dopamine antagonist, on the secretion of aldosterone and other adrenocortical steroids in normal subjects. An i.v. bolus injection of 10 mg of metoclopramide significantly increased the plasma PRL, plasma aldosterone and 18-hydroxycorticosterone, but the plasma renin activity, plasma deoxycorticosterone, corticosterone and cortisol remained unchanged. The changes in plasma aldosterone induced by metoclopramide were significantly correlated with the basal levels of plasma aldosterone and renin activity. These results suggest that the response of plasma aldosterone to metoclopramide in normal subjects is influenced by the basal activity of renin-angiotensin-aldosterone system and the late step of aldosterone synthesis is stimulated by metoclopramide.
本研究的目的是确定多巴胺拮抗剂甲氧氯普胺对正常受试者醛固酮及其他肾上腺皮质类固醇分泌的影响。静脉推注10毫克甲氧氯普胺可显著提高血浆泌乳素、血浆醛固酮和18-羟皮质酮水平，但血浆肾素活性、血浆脱氧皮质酮、皮质酮和皮质醇水平保持不变。甲氧氯普胺诱导的血浆醛固酮变化与血浆醛固酮和肾素活性的基础水平显著相关。这些结果表明，正常受试者血浆醛固酮对甲氧氯普胺的反应受肾素-血管紧张素-醛固酮系统基础活性的影响，且甲氧氯普胺刺激醛固酮合成的后期步骤。
