屋尘螨变应原支气管激发后的迟发反应。对花生四烯酸代谢的依赖性。
The late reaction following bronchial provocation with house dust mite allergen. Dependence on arachidonic acid metabolism.
作者信息
Fairfax A J, Hanson J M, Morley J
出版信息
Clin Exp Immunol. 1983 May;52(2):393-8.
Abstract
The involvement of arachidonic acid metabolism in early and late bronchial reactions has been studied in four asthmatic subjects sensitive to Dermatophagoides pteronyssinus. Pre-treatment with either indomethacin (an inhibitor of the cyclo-oxygenase pathway) or benoxaprofen (an inhibitor of both cyclo-oxygenase and lipoxygenase pathways) failed to affect the amplitude, but did produce some foreshortening of the early response to allergen. If benoxaprofen is an effective inhibitor of SRS-A formation in vivo, then these observations question the role of SRS-A as a spasmogen in allergen-induced bronchospasm. Both drugs were effective inhibitors of the late reaction, implying involvement of cyclo-oxygenase products (endoperoxides, prostaglandins or thromboxanes) in the genesis of a late response to allergen.
摘要
在四名对尘螨过敏的哮喘患者中，研究了花生四烯酸代谢在早期和晚期支气管反应中的作用。用消炎痛（环氧化酶途径抑制剂）或苯氧布洛芬（环氧化酶和脂氧化酶途径抑制剂）预处理，虽未影响反应幅度，但确实使对过敏原的早期反应有所缩短。如果苯氧布洛芬在体内是SRS - A形成的有效抑制剂，那么这些观察结果对SRS - A作为过敏原诱导支气管痉挛中的致痉剂的作用提出了质疑。两种药物都是晚期反应的有效抑制剂，这意味着环氧化酶产物（内过氧化物、前列腺素或血栓素）参与了对过敏原晚期反应的发生。
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