布洛芬在人体中的药代动力学。I. 游离及总血药浓度-时间曲线下面积与剂量的关系。
Pharmacokinetics of ibuprofen in man. I. Free and total area/dose relationships.
作者信息
Lockwood G F, Albert K S, Gillespie W R, Bole G G, Harkcom T M, Szpunar G J, Wagner J G
出版信息
Clin Pharmacol Ther. 1983 Jul;34(1):97-103. doi: 10.1038/clpt.1983.136.
Ibuprofen kinetics were studied in 15 subjects after four oral doses. Plasma levels of both total and free ibuprofen were measured for 12 hr, and urine was collected for 48 hr after the doses. All subjects showed a nonlinear relationship between dose and total ibuprofen plasma AUC. Free ibuprofen plasma AUC, however, was linearly related to the dose, suggesting that oral clearance based on free drug was dose independent. Urinary recovery data indicated that efficiency of absorption was dose independent.
在15名受试者口服四次剂量后对布洛芬动力学进行了研究。测定了给药后12小时内血浆中总布洛芬和游离布洛芬的水平，并在给药后48小时收集尿液。所有受试者的剂量与总布洛芬血浆药时曲线下面积（AUC）之间均呈现非线性关系。然而，游离布洛芬血浆AUC与剂量呈线性相关，这表明基于游离药物的口服清除率与剂量无关。尿回收率数据表明吸收效率与剂量无关。
Zotero 插件