Davis A, Morris J M, Tang S W
Eur J Pharmacol. 1983 Apr 8;88(4):407-10. doi: 10.1016/0014-2999(83)90595-2.
[3H]Imipramine binding sites are located on serotonergic nerve terminals and on blood platelets. Previous studies on our laboratories have indicated temperature-sensitive conformational changes in [3H]imipramine binding sites in hippocampal and cerebral cortex membranes. We now report that similar changes are observed in both membrane-bound and digitonin-solubilized [3H]imipramine binding sites of human blood platelets. This may indicate integrity of the solubilized binding site.
[3H]丙咪嗪结合位点位于血清素能神经末梢和血小板上。我们实验室之前的研究表明，海马体和大脑皮层膜中[3H]丙咪嗪结合位点存在温度敏感的构象变化。我们现在报告，在人血小板的膜结合和洋地黄皂苷增溶的[3H]丙咪嗪结合位点中均观察到类似变化。这可能表明增溶结合位点的完整性。
